Recombinant Factor VIII Fc Fusion Protein Inhibits Inflammatory Osteoclast Formation in vitro

Hemophilia is a rare, X-linked recessive inherited bleeding disorder characterized by deficiency of coagulation factor VIII or factor IX activity. It has been associated with low bone mineral density (BMD) potentially due to predisposing factors that include physical inactivity caused by hemophilic arthropathy, vitamin D deficiency and other comorbidities such as HCV/HIV infection.

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